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​英訳サンプル:       7​


The presence of spreading infection is potentially life and/or limb threatening and so requires aggressive treatment. Individuals demonstrating clinical signs of systemic infection should have blood cultures taken and appropriate systemic antibiotic therapy should be implemented immediately.


Antibiotics are administered orally, parenterally and in some cases, topically. Most reduce bacterial numbers by targeting bacterial functions or growth processes.They have a relatively narrow band of effectiveness, with particular antibiotics being needed to treat specific species or strains of bacteria. However, there are problems with their use.


全身投与用の抗生剤は患者全体を治療するものであり、創傷部のみを対象としていない。そのため、正常細菌叢に影響を及ぼし、クロストリジウム・ディフィシレ(C. ディフィシレ)感染などの全身合併症や副作用を引き起こすことが多い。

Systemic antibiotics treat the whole patient, not just the wound. Therefore, they can affect normal flora, leading to unpleasant side effects and systemic complications such as Clostridium difficile (C.difficile) infections.


They require an adequate blood supply to reach the point of infection and so may be ineffective in treating wounds with high amounts of debris or in patients with underlying arterial disease.


Antibiotic resistance is a serious problem . Widespread, indiscriminate use of antibiotics is a major factor in the emergence of drug-resistant bacteria which has reduced the treatment options for many systemic infections. New antibiotic options are urgently needed, but no new antibiotic preparations are in development; this is a potential time-bomb for both emerging nations and the developed world. 


Topical antibiotics can provoke delayed hypersensitivity reactions.


Systemic antibiotics have limited effect on biofilm colonies.

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