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  • 平井 将秀


TUESDAY Jan. 29, 2013 -- People taking certain antidepressants, including Celexa and Lexapro, may have a slightly increased risk of developing an abnormal heart beat.


Researchers say the drugs, which are in a class of medications called selective serotonin reuptake inhibitors (SSRIs), may extend the length of electrical activity in the heart, called a QT interval. A long QT interval is an indicator of abnormal heart rhythms.


"For people who are taking higher doses of citalopram (Celexa) or escitalopram (Lexapro), they should discuss these doses with their doctors," said lead researcher Dr. Roy Perlis, director of the Center for Experimental Drugs and Diagnostics in the psychiatry department at Massachusetts General Hospital in Boston.

「高用量のシタロプラム(セレクサ)やエスシタロプラム(レクサプロ)を服用している患者は、その用量について医師と話し合う必要がある」と、ボストンのマサチューセッツ中央病院精神科実験的薬剤および診断センターのRoy Perlis研究長は話している。

The report was published in the Jan. 29 online edition of the journal BMJ.


Doctors use an electrocardiogram (ECG) to measure the QT interval. The interval varies with heart rate, lengthening when the heart beats slower and shortening when the heart beats faster.


The normal QT interval for men is less than 420 milliseconds and for women it is less than 440 milliseconds. When the timing gets longer, the risk for abnormal heart rhythms increases, the researchers noted.


The U.S. Food and Drug Administration warned recently that Celexa and drugs like it could cause this problem.


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